MECHANISMS CONTRIBUTING TO INHIBITION OF RETINAL GANGLION CELL DEATH BY CELL PERMEABLE PEPTAIN-1 UNDER GLAUCOMATOUS STRESS

Mechanisms contributing to inhibition of retinal ganglion cell death by cell permeable peptain-1 under glaucomatous stress

Abstract This study assesses the neuroprotective potential of CPP-P1, a conjugate of an anti-apoptotic peptain-1 (P1) and a cell-penetrating peptide (CPP) in in vitro, in vivo, and ex vivo glaucoma models.Primary retinal ganglion cells (RGCs) were subjected to either neurotrophic factor (NF) deprivation for 48 h or endothelin-3 (ET-3) treatment for

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dSETDB1 and SU(VAR)3-9 sequentially function during germline-stem cell differentiation in Drosophila melanogaster.

Germline-stem cells (GSCs) produce gametes and are thus true "immortal stem cells".In Drosophila ovaries, GSCs divide asymmetrically to produce daughter Yeast Extract GSCs and cystoblasts, and the latter differentiate into germline cysts.Here we show that the histone-lysine methyltransferase dSETDB1, located in pericentric heterochromatin, catalyze

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Attitude to Immigrants in the Mass Consciousness of Europeans (using the example of secondary analysis of ESS 2016 data)

The article describes the experience of improving the methodology for identifying diversity and homogeneity in the behaviour of complex social objects.The subject area of the study in it is, on the one hand, methods of obtaining sociological knowledge of them adequate to the semantics of social processes, and on the other, specific areas of the pro

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Using analytical methods as part of strategic planning for an astronomical observatory housed in a public research institute

Research was conducted for the Large Millimeter Telescope Alfonso Serrano (LMT), a joint project between the US and Mexico.A Balanced Scorecard (BSC) was created based on the approach suggested by Niven in 2008.Eleven indicators and seven Round Dish strategic objectives were noted, and a performance measure, goal, type of monitoring, and Powered Ri

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